Mechanochemistry and solubilization of drugs

Abstract

The results on solubilization of poorly water-soluble drugs, indomethacin, piroxicam, and meloxicam, with the help of mechanochemical methods are presented. The mechanocomposites of the drugs with various excipients, including soluble polymers and non-soluble fine porous inorganic oxides, were obtained by co-grinding using vibrational and planetary centrifugal mills. The samples obtained revealed higher release rate and apparent solubility of the drugs with respect to the initial ones. Nevertheless, in some cases, e.g. for composites of piroxicam with alumina and ferric oxide, decreasing the release rate and solubility of the drug was observed suggesting the formation of poorly soluble strong drug - carrier associates.