Mechanochemistry and solubilization of drugs

The results on solubilization of poorly water-soluble drugs,
indomethacin, piroxicam, and meloxicam, with the help of
mechanochemical methods are presented. The mechanocomposites
of the drugs with various excipients, including soluble
polymers and non-soluble fine porous inorganic oxides, were
obtained by co-grinding using vibrational and planetary
centrifugal mills. The samples obtained revealed higher release rate and apparent solubility of the drugs with respect to the initial ones. Nevertheless, in some cases, e.g. for composites of piroxicam with alumina and ferric oxide, decreasing the release rate and solubility of the drug was observed suggesting the formation of poorly soluble strong drug - carrier associates.