Mesenchymal cell response to nanosized biphasic calcium phosphate composites

Guha, Avijit and Singh, Sashi and Kumaresan, R and Nayar, S and Sinha, Arvind (2009) Mesenchymal cell response to nanosized biphasic calcium phosphate composites. Colloids and Surfaces B: Biointerfaces, 73 (1). pp. 146-151.

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Biphasic calcium phosphate nanoparticles comprising both hydroxyapatite (HA) and β polymorph of tricalcium phosphate (β-TCP) have been synthesized together by a polymer matrix mediated process. The process, based on in situ mineralization of poly (vinyl alcohol), exerts a good control over the morphological features of biphasic nanoparticles. By controlling the reaction chemistry (Ca:P ratios), nanobioceramic particles having three different HA/β-TCP ratios of 50:50, 55:45 and 60:40 respectively. As the two constituents of biphasic system (HA and β-TCP) facilitate series of signaling cascades in osteoblast division and differentiation, the adhesion and differentiation properties of mesenchymal cells (MSCs) derived from bone marrow has been studied.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Nanocomposites; Biphasic calcium phosphate; Biomimetic; Mesenchymal stem cells
Divisions:Material Science and Technology
ID Code:664
Deposited By:Sahu A K
Deposited On:02 Jun 2010 12:13
Last Modified:21 Jul 2010 20:47
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