On the existence of a dynamic critical point by using wet milling on (±) modafinil

Linol, Julie and Martinetto, Pauline and Anne, Michel and Coquerel, Gérard (2011) On the existence of a dynamic critical point by using wet milling on (±) modafinil. In: VI International Conference on Mechanochemistry and Mechanical Alloying (INCOME 2008), 1-4 December 2008, NML Jamshedpur, India.



This study has been carried out on the molecular compound (±) modafinil, which exhibits five pure polymorphic forms (I, III, IV, V and VI). At P = 1 atm, irrespective of temperature and without any milling energy, Form I is the stable form. Therefore, the other polymorphic forms (III, IV, V and VI) are of monotropic character. The steady states of (±) modafinil have been investigated as a function of wet milling parameters (milling intensity and water concentration). The results presented here suggest the existence of a dynamic critical point defined by Tc ≈ 40°C, Pc ≈ 1 atm, Ic ≈ k R; R=50, Xc = 2% mass percent of water, respectively the critical: mean temperature, global pressure, milling intensity proportional to R and water composition (in mass percent).

Item Type:Conference or Workshop Item (Paper)
Official URL/DOI:http://eprints.nmlindia.org/5008
Uncontrolled Keywords:Molecular compound, (±) Modafinil, Mechanical activation, Wet milling, Milling energy, Polymorphic transformations
Divisions:Metal Extraction and Forming
ID Code:5008
Deposited On:19 Apr 2012 11:42
Last Modified:19 Apr 2012 11:42
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