Anodic oxidation of ketofrofen-an anti-inflammatory drug using boron doped diamond electrode

Murugananthan, M and Latha, S S and Bhaskar Raju, G and Yoshihara, S (2010) Anodic oxidation of ketofrofen-an anti-inflammatory drug using boron doped diamond electrode. Journal of Hazardous Materials, 180 . pp. 753-758.



The mineralization of ketoprofen (KP) by anodic oxidation was studied by employing boron doped diamond (BDD) and Pt electrodes. The redox behavior of KP molecule, fouling of electrodes, generation of oxygen and active chlorine species were studied by cyclic voltammetry. The effect of electrolyte, pH of aqueous medium and applied current density on the mineralization behavior of KP was also investigated. The degradation and mineralization were monitored by UV–vis spectrophotometer and total organic carbon analyzer, respectively. The results were explained in terms of in situ generation of hydroxyl radical (•OH), peroxodisulfate (S2O8 2−), and active chlorine species (Cl2, HOCl, OCl−). The physisorbed •OH on BDD was observed to trigger the combustion of KP in to CO2 and H2O. The poor mineralization at both BDDand Pt anodes in the presence of NaCl as supporting electrolyte was ascribed to the formation of chlorinated organic compounds which are refractory. Complete mineralization of KP molecule was achieved using Na2SO4 as supporting electrolyte.

Item Type:Article
Official URL/DOI:doi:10.1016/j.jhazmat.2010.05.007
Uncontrolled Keywords:Boron doped diamond, Ketoprofen, Hydroxyl radicals Active chlorine species, Mineralization, current efficiency
Divisions:NML Chennai > Mineral Processing
ID Code:4018
Deposited By:Dr. G Bhaskar Raju
Deposited On:25 Sep 2011 16:19
Last Modified:25 Sep 2011 16:19
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