Biomimetic patterning of polymer hydrogels with hydroxyapatite nanoparticles

Sinha, Arvind and Guha, Avijit (2009) Biomimetic patterning of polymer hydrogels with hydroxyapatite nanoparticles. Materials Science and Engineering: C, 29 (4). pp. 1330-1333.



We report here an in situ process to produce nano-composite polymer hydrogels having surfaces patterned with hydroxyapatite (HA) nanoparticles (100 nm). Poly (vinyl alcohol) (PVA) has been used as a hydrogel forming medium. A three step process, comprising precipitation of HA nanoparticles in presence of PVA molecules and freeze thawing of obtained PVA-HA emulsion, followed by critical point drying, has been devised to produce three dimensional nanocomposite hydrogels. Interaction of Ca2+ with oxygen atoms of PVA and the hydrogen bonding characteristic of the polymer have been exploited to have controlled size distribution of HA in a continuous and macroporous network of PVA. A systematic variation in the polymer concentration could be correlated with microstructural features of the hydrogel.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Biomimetic; Tissue Engineering; Hydroxyapatite; Poly (vinyl alcohol); Scaffolds
Divisions:Material Science and Technology
ID Code:26
Deposited By:Dr. A K Sahu
Deposited On:22 Sep 2009 15:59
Last Modified:09 Feb 2012 13:11
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