Dwivedi, Awadesh and Kumari, Arya and Aarthy, Murali and Singh, S K and Ojha, Monalisha and Jha, Suman and Jha, S K and Jha, N S (2021) Spectroscopic and molecular docking studies for the binding and interaction aspects of curcumin-cysteine conjugate and rosmarinic acid with human telomeric G-quadruplex DNA. International Journal of Biological Macromolecules, 182 . pp. 1463-1472.
Full text not available from this repository.
The binding and interaction aspects of potential anticancer ligands like: curcumin-cysteine (CC) and rosmarinic acid (RA) with human telomeric G-quadruplex DNA, a novel anticancer target, have been probed by spectroscopic and molecular docking approach. The circular dichroism study unravels the conformational switching from mixed hybrid to parallel structure for the short sequence of human telomeric G-quadruplex structure in the presence of both the ligands. Further a good correlation for binding affinity has been established from the emission and absorption binding spectrum analysis. Further our spectroscopic and molecular docking studies have suggested that the CC having better binding capability than RA to human telomeric G-quadruplex. The presence of L-cysteine moiety in CC ligand is responsible factor for its binding via both minor as well as major groove of human telomeric G-quadruplex DNA where-as RA binds only via minor groove of telomeric G-DNA. (c) 2021 Published by Elsevier B.V.
|Uncontrolled Keywords:||G-quadruplex; Curcumin cysteine; Rosmarinic acid; Binding; Circular dichorism; Spectroscopy; Molecular docking|
|Divisions:||Corrosion and Surface Engineering|
|Deposited By:||Dr. A K Sahu|
|Deposited On:||29 Jul 2021 15:15|
|Last Modified:||29 Jul 2021 15:15|
Repository Staff Only: item control page