Anomalously Augmented Charge Transport Capabilities of Biomimetically Transformed Collagen Intercalated Nanographene-Based Biocolloids

Abstract

Collagen microfibrils biomimetically intercalate graphitic structure in aqueous media to form graphene nanoplatelet collagen complexes (G-Cl). -Synthesized G-Cl-based Stable, aqueous bionanocolloids exhibit anomalously augmented charge transportation capabilities oversimple collagen or graphene based colloids. The concentration tunable electrical transport properties of :synthesized aqueous G-Cl bionanotaoids has been experimentally observed, theoretically analyzed, and mathematically modeled. A comprehensive approach to inathematically predict the electrical transport properties of simple graphene and collagen bed colloids has been presented. A theoretical formulation to explain the augmented transport characteriSties of the G-Cl bionanocolloids based on the physicochemical interactions among the two entities, as revealed from extensive characterizations of the G-Cl biocomplex, has also been proposed. Physical interactions between the zwitterionic amino acid molecules within the collagen triple helix with the polar water molecules and the,delocalized pi electrons of graphene and subsequent formation of partially charged entities has been found to be the crux mechanism behind the augmented transport phenomena. The analysis has been observed to accurately predict the degree of enhancement in transport of the concentration tunable composite colloids over the base colloids. The electrically active G-Cl bionanocolloids with concentration tunability promises find dual utility in novel gel bioelectrophoresis-based protein separation techniques and advanced surface charge inodulated drug delivery using biocolloids.