Bovine Serum Albumin Binding and Drug Delivery Studies with PVA-Ferrofluid

Nayar, S and Mir, Aparna and Ashok, Aarti and Guha, Avijit and Sharma, Vikas (2010) Bovine Serum Albumin Binding and Drug Delivery Studies with PVA-Ferrofluid. Journal of Bionic Engineering, 7 (1). pp. 29-34.

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This paper describes a single-step method for the biomimetic synthesis of stably suspended magnetite nanoparticles in poly(vinyl alcohol) termed ferrofluids. The challenge is to synthesize water based stable magnetic colloids with a control over the particle size and morphology for biomedical applications. The polymer possibly plays a dual role of a surfactant and a functionalizing agent. Transmission electron microscopy, infrared spectroscopy and vibrating sample magnetometry were used to investigate the properties of the synthesized ferrofluids. It has a strong affinity towards the tryptophan residues in bovine serum albumin protein as determined from the fluorescence emission studies. For in vivo applications this could indirectly mean a resistance to immune response and thus ensure long–term circulation. The ability of the synthesized ferrofluid to bind a chemotherapeutic drug ceftriaxone and its ionic release was observed. The polymer hydroxyl group allows drug-binding and the magnetic property allows targeting to specific sites. Magnetic hybrid fluids with combined advantages of magnetism and polymer open up new perspectives for applications

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:biomimetic synthesis; ferrofluids; poly (vinyl alcohol); bovine serum albumin; superparamagnetism
Divisions:Material Science and Technology
ID Code:476
Deposited By:Sahu A K
Deposited On:13 May 2010 10:20
Last Modified:06 Feb 2012 17:03

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